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While no significant alterations in pulsatility were observed, AQP4 polarization was remarkably impaired and GFAP expression increased in APP-PS1 mice

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Metabolites associated with alanine metabolism that were significantly decreased in biofilm were 1,3-diaminopropane (FC = 0.02, p = 4.99 10 -3 ), putrescine (FC = 0.04, p = 3.12 10 -6 ), beta-alanine (FC = 0.05, p = 4.36 10 -3 ), alanine (FC = 0.16, p = 3.31 10 -3 ), gamma-aminobutyric acid (FC = 0.31, p = 9.96 10 -5 ), and aspartate (FC = 0.31, p = 1.96 10 -3 )

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